abstract：:This article describes methods and issues that are specific to the assessment of change in tumor characteristics as measured using quantitative magnetic resonance (MR) techniques and how this relates to the establishment of quantitative MR imaging (MRI) biomarkers of patient response to therapy. The initial focus is o...

journal_title：Translational oncology

authors： Jackson EF,Barboriak DP,Bidaut LM,Meyer CR

更新日期：2009-12-01 00:00:00

abstract：:Migration is a complex process that, besides its various physiological functions in embryogenesis and adult tissues, plays a crucial role in cancer cell invasion and metastasis. The focus of this study is the involvement and collaboration of Akt, focal adhesion kinase (FAK), and Src kinases in migration and invasivene...

journal_title：Translational oncology

authors： Turecková J,Vojtechová M,Krausová M,Sloncová E,Korínek V

更新日期：2009-12-01 00:00:00

abstract：:Liver cancers in children are rare representing only 1.1% of malignancies, with an annual incidence rate of 1.5 cases per million. Hepatoblastoma and hepatocellular carcinomas are the most common malignancies of the liver occurring in young people aged 15 years or younger. Molecular basis of both tumors are still uncl...

journal_title：Translational oncology

authors： Magrelli A,Azzalin G,Salvatore M,Viganotti M,Tosto F,Colombo T,Devito R,Di Masi A,Antoccia A,Lorenzetti S,Maranghi F,Mantovani A,Tanzarella C,Macino G,Taruscio D

更新日期：2009-08-18 00:00:00

abstract：:SPARC up-regulation is a poor prognostic factor in head and neck cancer. It was hypothesized that because of a SPARC-albumin interaction, tumoral SPARC facilitates the accumulation of albumin in the tumor and increases the effectiveness of albumin-bound paclitaxel (nab-paclitaxel). This hypothesis was tested by correl...

journal_title：Translational oncology

authors： Desai N,Trieu V,Damascelli B,Soon-Shiong P

更新日期：2009-05-01 00:00:00

abstract：:DNA damage has been associated with prostate cancer risk. Men who were referred for initial prostate biopsy for elevated prostate-specific antigen or abnormal digital rectal examination are often found with no cancer but have a higher risk of developing prostate cancer than the general population of men in their lifet...

journal_title：Translational oncology

authors： Wu JD,Lin DW,Page ST,Lundgren AD,True LD,Plymate SR

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:Angiogenesis plays an important role in pancreas cancer pathobiology. Pancreatic tumor cells secrete vascular endothelial growth factor (VEGF), activating endothelial cell protein kinase C beta (PKCbeta) that phosphorylates GSK3beta to suppress apoptosis and promote endothelial cell proliferation and microvesse...

journal_title：Translational oncology

authors： Spalding AC,Zeitlin BD,Wilder-Romans K,Davis ME,Nor JE,Lawrence TS,Ben-Josef E

更新日期：2008-12-01 00:00:00

abstract：INTRODUCTION:Many genes are differentially expressed between androgen-dependent and androgen-independent prostate cancer (CaP). Differential expression analysis and subtractive hybridization previously identified nine genes expressed in intact mice bearing CWR22 tumors and castrated mice bearing recurrent CWR22 tumors ...

journal_title：Translational oncology

authors： Singh SS,Li Y,Ford OH,Wrzosek CS,Mehedint DC,Titus MA,Mohler JL

更新日期：2008-09-01 00:00:00

abstract：:Checkpoint with FHA and RING finger domains (CHFR) was first recognized as an early mitotic checkpoint protein that delayed the cell cycle in response to microtubule-targeting drugs. It is an E3 ubiquitin ligase that ubiquitinates target proteins to direct them to the proteasome for degradation or to alter their activ...

journal_title：Translational oncology

authors： Privette LM,Petty EM

更新日期：2008-07-01 00:00:00